Anti-TOP3A Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-TOP3A Rabbit Polyclonal Antibody

Anti-TOP3A Rabbit Polyclonal Antibody

14525-1-AP-150UL

10096-202EA 537.7 USD

10096-202

Anti-TOP3A Rabbit Polyclonal Antibody

Antibodies

DNA topoisomerase 3-alpha (TOP3A) is an essential component of the RMI complex, a complex involves in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. It releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. This antibody is specific to react with the 110kd human TOP3A.

Western Blot:K-562 Cells, 1:500-1:5000

Type: Primary
Antigen: TOP3A
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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