Anti-MYBBP1A Rabbit Polyclonal AntibodySupplier: Proteintech
10090-672EA 402 USD10090-672
Anti-MYBBP1A Rabbit Polyclonal Antibody
The protooncogene MYB is predominantly expressed in immature hemopoietic cells where it has an essential role in hemopoietic cell proliferation and differentiation. Oncogenically activated forms of MYB is generally N- and/or C-terminal truncations of the normal MYB protein. Removal of the C terminus of MYB disrupts or deletes a region termed the negative regulatory domain (NRD), resulting in an increase in DNA binding, transactivation, and transformation by MYB. One feature of the NRD is a leucine zipper-like motif . Murine Myb-binding protein-1a (MYBBP1A), originally called P160, was identified by its ability to interact specifically with Myb via this leucine zipper-like motif. MYBBP1A modulates MYB activity upon binding to the MYB NRD .
Western Blot: HeLa Cells, 1:500-1:5000; IHC: Human Kidney Tissue, 1:20-1:200; IF: HepG2 Cells, 1:20-1:200; FC: HepG2 Cells, N/A
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