The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis . SYT1 (synaptotagmin I) was firstly identified as a 65-kDa protein with a wide distribution in neuronal and neurosecretory tissue . Calcium binding to SYT1 participates in triggering neurotransmitter release at the synapse . In addition to regulating exocytosis, SYT1 has also been implicated in endocytosis and neurite outgrowth . This antibody recognizes endogenous SYT1, which has an experimentally determined molecular mass of 65-68 kDa. An additional band of 47 kDa could also be detected, which is corresponding to the calculated molecular weight of SYT1.
Western Blot: Human Liver Tissue, 1:200-1:2000; IHC: Human Liver cancer Tissue, 1:20-1:200
Type: Primary
Antigen: SYT1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse