Anti-NUB1 Rabbit Polyclonal Antibody

Supplier: Proteintech
10091-350EA 402 USD
Anti-NUB1 Rabbit Polyclonal Antibody
Proteasome-associated protein NEDD8 ultimate buster 1 (NUB1) is an interferon-inducible protein that down-regulates NEDD8 expression and its conjugation system. Over-expression of NUB1 induces a growth-inhibitory effect in cells, and it mediates anti-proliferative actions and apoptosis in renal cell carcinoma cells through cell-cycle regulation. Expression of NUB1 leads to decreased modification of p53 with NEDD8 and stimulation of p53 ubiquitination. Recent finding revealed that NUB1, by regulating GSK3β levels, modulates tau phosphorylation and aggregation, and is a key player in neurodegeneration associated with tau pathology.

Western Blot: HeLa Cells, 1:200-1:2000; IP: HEK-293 Cells, 1:200-1:2000

Type: Primary
Antigen: NUB1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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