Anti-REN Rabbit Polyclonal Antibody

Supplier: Proteintech
10093-514EA 402 USD
Anti-REN Rabbit Polyclonal Antibody
REN(Renin) is also named as angiotensinogenase and belongs to the peptidase A1 family. It is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Human prorenin and renin are synthesized in juxtaglomerular cells and it locates in the juxtaglomerular cells and afferent arteriole as cytoplasmic granules. This protein has a signal peptide of 23 amino acid and a propeptide of 43 amino acid. It has 2 isoforms produced by alternative splicing and two glycosylation sites. Defects in REN are a cause of renal tubular dysgenesis (RTD) and familial juvenile hyperuricemic nephropathy type 2 (HNFJ2).

Western Blot: Mouse Heart Tissue, 1:200-1:1000; IHC: Human Kidney Tissue, 1:20-1:200; IF: HepG2 Cells, 1:20-1:200

Type: Primary
Antigen: REN
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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