Anti-Nicastrin Rabbit Polyclonal Antibody

Supplier: Proteintech
10091-100EA 402 USD
Anti-Nicastrin Rabbit Polyclonal Antibody
Nicastrin (NCT) is a type I transmembrane glycoprotein, which forms high molecular weight gamma-secretase complexes with with presenilin 1 and presenilin 2 . The gamma-secretase is an intramembrane protease cleaves many type I membrane proteins including amyloid precursor protein (APP) and Notch, generating peptide fragments that are important signaling components . The proteolytical processing of APP results in the release of amyloid-βpeptide, a principal component of the plaques found in the brains of Alzheimer’s disease patients .

Western Blot: Mouse Brain Tissue, 1:500-1:5000

Type: Primary
Antigen: Nicastrin
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR