Anti-IGFBP1 Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-IGFBP1 Rabbit Polyclonal Antibody

Anti-IGFBP1 Rabbit Polyclonal Antibody

Anti-IGFBP1 Rabbit Polyclonal Antibody

Anti-IGFBP1 Rabbit Polyclonal Antibody

13981-1-AP-150UL

10088-660EA 402 USD

10088-660

Anti-IGFBP1 Rabbit Polyclonal Antibody

Antibodies

Insulin-like growth factor (IGF)-binding proteins (IGFBPs) family contains members like IGFBP-1, -2, -3, -4,-5 and-6. IGFBPs prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGF-I physically interacts with IGFBP-1 and that IGFBP-1 also binds to an integrin receptor, but the effect of IGFBP-1 on cell migration may be independent of IGF-I and is probably mediated through the alpha 5 beta 1 integrin. Transgenic mice models demonstrated that IGFBPs played important roles in the pathogenesis of obesity and insulin resistance. Studies conducted in humans demonstrated the close relation between IGFBPs and the components of the metabolic syndrome.

Western Blot: Human Placenta Tissue, 1:200-1:1000; IHC: Human Placenta Tissue, 1:20-1:200

Type: Primary
Antigen: IGFBP1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human

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