SERPINE1, also named as Plasminogen activator inhibitor type 1 (PAI-1), is a member of the serine protease inhibitor (SERPIN) superfamily. PAI-1 is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. In western blotting, we got two bands 55 kDa and 110 kDa, and we are unsure as to the identity of the extra 110 kDa band.
Western Blot:SH-SY5Y Cells, 1:200-1:2000; IHC: Human pancreas cancer Tissue, 1:20-1:200; IP:SH-SY5Y Cells, 1:200-1:1000
Type: Primary
Antigen: PAI1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat