Anti-MTUS1 Rabbit Polyclonal Antibody

Supplier: Proteintech
10090-586EA 402 USD
Anti-MTUS1 Rabbit Polyclonal Antibody
MTUS1, also named as ATBP, ATIP, GK1, KIAA1288 and MTSG1, Belongs to the MTUS1 family. It cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. MTUS1 may be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. MTUS1 up-regulation during cellular transition from proliferation to quiescence and differentiation. It is a potential tumor suppressor gene located at chromosome 8p21.3.22, near marker D8S254. According to the functional data and intracellular localization, MTUS1 also named as mitochondrial tumor suppressor gene 1 (MTSG1). One main feature common to all ATIP members is the presence of a large C-terminal coiled-coil domain that allows homo- and hetero-dimerization of these proteins. The antibody can recognize all the isoforms except isoform 5 (85-90kd). The antibody tested HomoDimer isoforms (80kd/110-120/280kd) in Jurkat cell.

Western Blot:Jurkat Cells, 1:500-1:5000; IP: Mouse Brain Tissue, 1:200-1:2000

Type: Primary
Antigen: MTUS1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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