Human acid lipase/cholesteryl esterase (LIPA) is a 46-kDa glycoprotein required for the lysosomal hydrolysis of cholesteryl esters and triglycerides that cells acquire through the receptor-mediated endocytosis of low-density lipoproteins. Defects in LIPA are the cause of Wolman disease (WOD) and cholesteryl ester storage disease (CESD). It has 2 isoforms produced by alternative splicing with the molecular weight of 45 kDa and 39 kDa. The full length protein has a signal peptide and several glycosylation sites.
Western Blot:Y79 Cells, 1:200-1:2000; IHC: Human Colon cancer Tissue, 1:20-1:200
Type: Primary
Antigen: LIPA
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat