Anti-TMPRSS6 Rabbit Polyclonal Antibody

Supplier: Proteintech
12950-1-AP-150UL
10096-104EA 402 USD
10096-104
Anti-TMPRSS6 Rabbit Polyclonal Antibody
Antibodies
The type II transmembrane serine protease TMPRSS6 (also known as matriptase-2) controls iron homeostasis through its negative regulation of expression of hepcidin, a key hormone involved in iron metabolism. Upstream of the hepcidin-regulated signaling pathway, TMPRSS6 cleaves its target substrate hemojuvelin (HJV) at the plasma membrane.It Belongs to the peptidase S1 family.Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA).It has 4 isoforms produced by alternative splicing.

Western Blot: HEK-293 Cells, 1:200-1:2000

Type: Primary
Antigen: TMPRSS6
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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