CBLB(E3 ubiquitin-protein ligase CBL-B) is also named as RNF56 ans plays a necessary role to prevent the inappropriate activation of NF-B in response to lipopolysaccharide and to polymicrobial sepsis. CBLB can be phosphorylated on tyrosine and serine residues upon TCR or BCR activation, and upon various types of cell stimulation.. It also has a crucial role in the prevention of chronic inflammation and autoimmunity. This protein has 4 isoforms produced by alternative splicing.
Western Blot: HEK-293 Cells, 1:500-1:5000; IHC: Human lung cancer Tissue, 1:20-1:200; IF: HepG2 Cells, 1:20-1:200
Type: Primary
Antigen: CBLB
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat