Anti-TTP Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-TTP Rabbit Polyclonal Antibody

Anti-TTP Rabbit Polyclonal Antibody

Anti-TTP Rabbit Polyclonal Antibody

Anti-TTP Rabbit Polyclonal Antibody

Anti-TTP Rabbit Polyclonal Antibody

Anti-TTP Rabbit Polyclonal Antibody

12737-1-AP-150UL

10097-266EA 402 USD

10097-266

Anti-TTP Rabbit Polyclonal Antibody

Antibodies

The expression of many cytokines is regulated post-transcriptionally by factors that modulate mRNA transport, translation, and stability. Much of this regulation occurs by the binding and stabilizing, or destabilizing, of cytokine mRNAs by proteins that recognize adenosine and uridine-rich elements (AREs) in untranslated regions of target transcripts. Zfp36 is a mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. It was demonstrated to physically interact with the p65 subunit of nuclear factor-κB leading to decreased nuclear import and diminished transcriptional activation mediated by nuclear factor-κB. It acted by specifically binding ARE-containing mRNAs and promoting their degradation, and has a crucial role in the post-transcriptional regulation of tumor necrosis factor (TNF).

Western Blot: Mouse lung Tissue, 1:200-1:2000; IF: HepG2 Cells, 1:10-1:100; IHC: Human breast cancer Tissue, 1:20-1:200

Type: Primary
Antigen: TTP
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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