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Anti-APPL1 Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-APPL1 Rabbit Polyclonal Antibody

Anti-APPL1 Rabbit Polyclonal Antibody

Anti-APPL1 Rabbit Polyclonal Antibody

Anti-APPL1 Rabbit Polyclonal Antibody

12639-1-AP-150UL

10081-938EA 459.7 USD

10081-938

Anti-APPL1 Rabbit Polyclonal Antibody

Antibodies

Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1), a binding partner of Akt2 and an important regulator of insulin signaling, plays a key role in the regulation of insulin secretion . APPL1 interacts with adiponectin receptors and mediates the insulin-sensitizing effects of adiponectin in muscle and endothelial cells. It also participates in nuclear signaling and transcriptional regulation, mostly by modulating the activity of various nuclear factors . Apart from its role in endocytosis and endosomal transport, APPL1 was reported to undergo nucleocytoplasmic shuttling and participate in transcriptional regulation, e.g. by interactions with histone deacetylases (HDACs) .

Western Blot: Human Brain Tissue, 1:500-1:5000; IHC: Human ovary tumor, 1:20-1:200

Type: Primary
Antigen: APPL1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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