Anti-RBBP8 Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-RBBP8 Rabbit Polyclonal Antibody

Anti-RBBP8 Rabbit Polyclonal Antibody

12624-1-AP-150UL

10093-380EA 402 USD

10093-380

Anti-RBBP8 Rabbit Polyclonal Antibody

Antibodies

RBBP8 is an endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. It functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. It interacted with BRCA1 to form a complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Also it promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations

Western Blot: Mouse Testis Tissue, 1:200-1:2000

Type: Primary
Antigen: RBBP8
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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