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Anti-SAMHD1 Rabbit Polyclonal Antibody

Supplier: Proteintech

SAMHD1, highly expressed by monocytes and monocyte-derived dendritic cells and by monocyte-derived macrophages at a lower extent, is reported as an HIV-1 restriction factor that inhibits the early step of the HIV-1 life cycle. Vpx (virus-like particles containing viral protein X) could overcome this block by interacting with SAMHD1, inducing proteasome-dependent degradation of SAMHD1. Mutations in SAMHD1 cause Aicardi-Goutières syndrome, a genetic encephalopathy with a presumed immune pathogenesis. This antibody 12586-1-AP is raised againt N-terminal 314 amino acids of the full length SAMHD1.

Western Blot: HepG2 Cells, 1:500-1:5000; IHC: Human lung cancer Tissue, 1:20-1:200; IP:K-562 Cells, 1:200-1:1000

Type: Primary
Antigen: SAMHD1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat




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Size Supplier No. VWR Catalog Number Unit Price Quantity
150 µL 12586-1-AP 10094-128 Each (150µl) Retrieving Restricted
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SPECIFICATIONS

Antibody Type Primary
Antigen Name Sam Domain And Hd Domain 1
Antigen Symbol SAMHD1
Antigen Synonyms dendritic cell-derived IFNG-induced protein, DCIP, monocyte protein 5, HDDC1, MOP-5, CHBL2, SAM domain and HD domain-containing protein 1, SBBI88
Clonality Polyclonal
Conjugation Unconjugated
ELISA Yes
Host Rabbit
ImmunoChemistry Yes
ImmunoPrecipitation Yes
Immunogen Recombinant Protein
Isotype IgG
Purification Antigen affinity Purification
Reactivity Human, Rat, Mouse
Shipping Temperature Store at -20°C
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Western Blot Yes
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