Anti-PTBP1 Rabbit Polyclonal Antibody

Supplier: Proteintech
12582-1-AP-150UL
10081-416EA 459.7 USD
10081-416
Anti-PTBP1 Rabbit Polyclonal Antibody
Antibodies
Polypyrimidine tract-binding protein (PTBP1), also known as heterogeneous nuclear ribonucleoprotein type I (hnRNP I), is a nuclear protein that binds pre-mRNAs in specific regions of the hnRNA-protein complexes sensitive to micrococcal nuclease. It involves in pre-mRNA splicing and the regulation of alternative splicing events. PTBP1 promotes RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA, and promotes the binding of U2 snRNP to pre-mRNA. Besides, it can cooperate with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA, and represses the splicing of MAPT/Tau exon 10

Western Blot:Jurkat Cells, 1:1000-1:10000; IHC: Human Prostate Cancer Tissue, 1:20-1:200; IF:A2780 Cells, 1:10-1:100

Type: Primary
Antigen: PTBP1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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