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Anti-F12 Rabbit Polyclonal Antibody

Supplier: Proteintech

Factor XII (F XII, Hageman factor) is a 80kD, single chain glycoprotein that circulates in blood as an inactive zymogen. F XII plays an important role in blood coagulation, fibrinolysis, and kinin generation. When plasma comes into contact with negatively charged surfaces such as glass, kaolin, or dextran sulfate, F XII is bound to the surface and undergoes limited proteolysis by plasma kallikrein, resulting in two active enzyme forms, ɑ-F XIIa and β-F XIIa. ɑ-F XIIa consisting of a 28kD light chain containing the protease domain, and a 52kD heavy chain containing the anionic surface-binding domain. β-F XIIa consists of two disulfide-linked chains, a 2 kD light chain and a 28 kD heavy chain containing the catalytic domain. Defects in Factor XII do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.

Western Blot:Jurkat Cells, 1:200-1:2000; IHC: Human Liver Tissue, 1:20-1:200

Type: Primary
Antigen: F12
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat




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Size Supplier No. VWR Catalog Number Unit Price Quantity
150 µL 12551-1-AP 10086-756 Each (150µl) Retrieving Restricted
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SPECIFICATIONS

Antibody Type Primary
Antigen Name Coagulation Factor 12
Antigen Symbol F12
Antigen Synonyms HAEX, Coagulation Factor XII, Hageman Factor, HAF, HAE3
Clonality Polyclonal
Conjugation Unconjugated
ELISA Yes
Host Rabbit
ImmunoChemistry Yes
Immunogen Recombinant Protein
Isotype IgG
Purification Antigen affinity Purification
Reactivity Mouse, Human, Rat
Shipping Temperature Store at -20°C
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Western Blot Yes
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