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Anti-CHMP2B Rabbit Polyclonal Antibody

Supplier: Proteintech
CHMP2B, chromatin-modifying protein 2b, also named as CHMP2.5, VPS2B and VPS2 2, belongs to the chromatin-modifying protein / charged multivesicular body protein (CHMP) family. It is a component of endosomal sorting complex required for transport III (ESCRT-III), which involves in endosomal and autophagic trafficking of proteins to lysosomes for degradation. Mutations of CHMP2B lead to C-terminal truncation or been replaced with mis-splicing C-termini and cause frontotemporal lobar degeneration (FTLD). In CHMP2B mutation patients, p62- and ubiquitin-positive, but TDP-43 and FUS negative neural inclusions are formed, maybe caused by impaired lysosomal degradation through the autophagy and endosome-lysosome pathways.

Western Blot:SH-SY5Y Cells, 1:200-1:2000; IF: HepG2 Cells, 1:10-1:100; IHC: Human Liver Tissue, 1:20-1:200

Type: Primary
Antigen: CHMP2B
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit



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Size Supplier No. VWR Catalog Number Unit Price Quantity
150 µL 12527-1-AP 10084-718 Each (150µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Antigen Symbol CHMP2B
Antigen Name Charged Multivesicular Body protein 2B
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
Antigen Synonyms Chromatin modifying Protein 2B, ALS17, VPS2B, CHMP2.5, VPS2-2, DMT1
Immunogen Recombinant Protein
Purification Antigen affinity Purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Shipping Temperature Store at -20°C
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