Anti-PLEK Rabbit Polyclonal Antibody

Supplier: Proteintech
12506-1-AP-150UL
10092-446EA 453 USD
10092-446
Anti-PLEK Rabbit Polyclonal Antibody
Antibodies
PLEK (pleckstrin; also known as p47) was originally identified as the major PKC substrate in platelets and later is found to be expressed in all cells of the hemopoietic system. Through two pleckstrin homology (PH) domains at its N and C termini, PLEK may interact with various protein and/or lipid ligands and serve as an intracellular adaptor/targeting protein. Predominantly cytosolic in unstimulated cells, PLEK would undergo transient redistribution to phagosomal membrane in response to stimuli. PLEK has been found to be hyperphosphorylated in diabetic mononuclear phagocytes and promote proinflammatory cytokine secretion in diabetes. (10477609, 17579087)

Western Blot:U-937 Cells, 1:500-1:5000; IHC: Human lung cancer Tissue, 1:20-1:200; IP:U-937 Cells, 1:500-1:5000

Type: Primary
Antigen: PLEK
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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