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Anti-CRTC2 Rabbit Polyclonal Antibody

Supplier: Proteintech

CRTC2, also named as TORC2, belongs to the TORC family. It is a transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. It acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. CRTC2 enhances the interaction of CREB1 with TAF4. Ir regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. CRTC2 regulates the expression of specific genes such as the steroidogenic gene, StAR. TORC2 was recently shown to be an important regulator of gluconeogenesis in the livers of mammals. It is one of the other key regulators of CRE-dependent MIE gene expression in NT2 cells. This regulation is linked to VIP-induced TORC2 dephosphorylation and translocation to the nucleus. .

Western Blot: HepG2 Cells, 1:500-1:5000; IHC: Human gliomas Tissue, 1:20-1:200; IF: Hela Cells, 1:20-1:200

Type: Primary
Antigen: CRTC2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity:




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Size Supplier No. VWR Catalog Number Unit Price Quantity
150 µL 12497-1-AP 10085-214 Each (150µl) Retrieving Restricted
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SPECIFICATIONS

Antibody Type Primary
Antigen Name CREB regulated transcription Coactivator 2
Antigen Symbol CRTC2
Antigen Synonyms TORC2, CREB-regulated transcription coactivator 2, TORC-2, Transducer of regulated cAMP response element-binding protein 2, CRTC2
Clonality Polyclonal
Conjugation Unconjugated
ELISA Yes
Host Rabbit
ImmunoChemistry Yes
ImmunoFluorescence Yes
Immunogen Recombinant Protein
Isotype IgG
Purification Antigen affinity Purification
Reactivity Mouse, Rat, Human
Shipping Temperature Store at -20°C
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Western Blot Yes
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