Anti-CREST Rabbit Polyclonal AntibodySupplier: Proteintech
10085-184EA 402 USD10085-184
Anti-CREST Rabbit Polyclonal Antibody
SS18-like 1(SS18L1) is a transcriptional activator that is required for calcium-dependent dendritic growth and branching in cortical neurons. It's also a nuclear protein interacts with CREB-binding protein and expressed in the developing brain. It helps regulate neuronal morphogenesis in calcuim-dependent manner. The N-terminal domain of SS18L1 is required for suppressing transactivation in the basal state, while the C-terminal domain is required for calcium-induced transactivation. It's part of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. This complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP
Western Blot:K-562 Cells, 1:500-1:5000; IHC: Human breast cancer Tissue, 1:20-1:200; IP: Mouse Brain Tissue, 1:500-1:5000
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