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Anti-CREST Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-CREST Rabbit Polyclonal Antibody

Anti-CREST Rabbit Polyclonal Antibody

Anti-CREST Rabbit Polyclonal Antibody

Anti-CREST Rabbit Polyclonal Antibody

12439-1-AP-150UL

10085-184EA 459.7 USD

10085-184

Anti-CREST Rabbit Polyclonal Antibody

Antibodies

SS18-like 1(SS18L1) is a transcriptional activator that is required for calcium-dependent dendritic growth and branching in cortical neurons. It's also a nuclear protein interacts with CREB-binding protein and expressed in the developing brain. It helps regulate neuronal morphogenesis in calcuim-dependent manner. The N-terminal domain of SS18L1 is required for suppressing transactivation in the basal state, while the C-terminal domain is required for calcium-induced transactivation. It's part of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. This complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP

Western Blot:K-562 Cells, 1:500-1:5000; IHC: Human breast cancer Tissue, 1:20-1:200; IP: Mouse Brain Tissue, 1:500-1:5000

Type: Primary
Antigen: CREST
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity:

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