Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Mutants of the DPH1, DPH2, and DPH5 (611075) genes, involved in diphthamide biosynthesis, were identified as resistant to both anthrax toxin and diphtheria toxin. This antibody works well in WB, IP, IHC and IF application.
Western Blot: Human Brain Tissue, 1:1000-1:10000; IHC: Human Colon cancer Tissue, 1:20-1:200; IP: Mouse Skeletal Muscle Tissue, 1:500-1:5000; IF:PC-3 Cells, 1:10-1:100
Type: Primary
Antigen: DPH2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse