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Anti-CXCL1 Rabbit Polyclonal Antibody

Supplier: Proteintech

CXCL1, also named as FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3 and SCYB1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene. It has chemotactic activity for neutrophils. CXCL1 may play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation,wound healing, and tumorigenesis.This chemokine elicits its effects by signaling through the chemokine receptor CXCR2. The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. An initial study in mice showed evidence that CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function.

Western Blot:COLO 320 Cells, 1:500-1:5000; IHC: Human ovary tumor Tissue, 1:20-1:200

Type: Primary
Antigen: CXCL1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity:




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Size Supplier No. VWR Catalog Number Unit Price Quantity
150 µL 12335-1-AP 10085-414 Each (150µl) Retrieving Restricted
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SPECIFICATIONS

Antibody Type Primary
Antigen Name Chemokine (C-X-C Motif) Ligand 1
Antigen Symbol CXCL1
Antigen Synonyms FSP, GRO1, MGSA-a, NAP-3, SCYB1, MGSA, GROa
Clonality Polyclonal
Conjugation Unconjugated
ELISA Yes
Host Rabbit
ImmunoChemistry Yes
Immunogen Recombinant Protein
Isotype IgG
Purification Antigen affinity Purification
Reactivity Mouse, Human
Shipping Temperature Store at -20°C
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Western Blot Yes
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