Anti-CXCL1 Rabbit Polyclonal Antibody

Supplier: Proteintech
12335-1-AP-150UL
10085-414EA 462.47 USD
10085-414
Anti-CXCL1 Rabbit Polyclonal Antibody
Antibodies
CXCL1, also named as FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3 and SCYB1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene. It has chemotactic activity for neutrophils. CXCL1 may play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation,wound healing, and tumorigenesis.This chemokine elicits its effects by signaling through the chemokine receptor CXCR2. The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. An initial study in mice showed evidence that CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function.

Western Blot:COLO 320 Cells, 1:500-1:5000; IHC: Human ovary tumor Tissue, 1:20-1:200

Type: Primary
Antigen: CXCL1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity:
Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR