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Anti-BMP7 Rabbit Polyclonal Antibody

Supplier: Proteintech

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.
BMP7, also known as osteogenic protein-1 or OP-1, plays a key role in the transformation of mesenchymal cells into bone and cartilage. BMP7 may be involved in bone homeostasis . It is expressed in the brain, kidneys and bladder. BMP7 is also present in cancers, including breast, prostate, and colon cancers, in which it is implicated in regulating cancer cell proliferation . Overexpression of BMP7 mRNA in colorectal cancer patients was significantly associated with poor prognosis and low overall survival . Recent studies suggest that high-expression level of BMP7 serves as a biomarker for poor prognosis for HCC .

Western Blot: HEK-293 Cells, 1:500-1:5000; IHC: Human renal cell carcinoma Tissue, 1:20-1:200

Type: Primary
Antigen: BMP7
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat




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Size Supplier No. VWR Catalog Number Unit Price Quantity
150 µL 12221-1-AP 10083-298 Each (150µl) Retrieving Restricted
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SPECIFICATIONS

Antibody Type Primary
Antigen Name Bone morphogenetic protein 7
Antigen Symbol BMP7
Antigen Synonyms Osteogenic protein 1, OP-1, BMP-7
Clonality Polyclonal
Conjugation Unconjugated
ELISA Yes
Host Rabbit
ImmunoChemistry Yes
Immunogen Recombinant Protein
Isotype IgG
Purification Antigen affinity Purification
Reactivity Rat, Human, Mouse
Shipping Temperature Store at -20°C
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Western Blot Yes
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