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Anti-NEIL1 Rabbit Polyclonal Antibody

Supplier: Proteintech

NEIL1, also named as NEH1 and FPG1, belongs to the FPG family. It is involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. NEIL1 acts as DNA glycosylase that recognizes and removes damaged bases. It has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. NEIL1 has marginal activity towards 8-oxoguanine. It has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. It cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. NEIL1 has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. The increased BER activity of NEILs may represent an adaptive response against ROS-induced DNA damage resulting from aniline exposure, and could be an important mechanism for the removal of oxidative DNA lesions.

Western Blot:A375 Cells, 1:200-1:2000

Type: Primary
Antigen: NEIL1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat




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Size Supplier No. VWR Catalog Number Unit Price Quantity
150 µL 12145-1-AP 10091-014 Each (150µl) Retrieving Restricted
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SPECIFICATIONS

Antibody Type Primary
Antigen Name Nei-Like Dna Glycosylase 1
Antigen Symbol NEIL1
Antigen Synonyms NEI1, hFPG1, FPG1, NEH1
Clonality Polyclonal
Conjugation Unconjugated
ELISA Yes
Host Rabbit
Immunogen Recombinant Protein
Isotype IgG
Purification Antigen affinity Purification
Reactivity Human, Mouse, Rat
Shipping Temperature Store at -20°C
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Western Blot Yes
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