Globin genes' expression in the β-globin cluster is restricted to erythroid cells, with five different genes expressed during embryonic (e), fetal (Gγ and Aγ), and adult (δ and β) development . Transcriptional activation of globin genes occurs not only by the binding of transcriptional activator proteins to the promoter of the gene being activated but also by a regulatory element located 6 to 18 kb upstream of the β-globin cluster, the locus control region (LCR). DXL4, also known as BP1, binds to two silencer DNA sequences upstream of the adult human β-globin gene and to a negative control region upstream of the adult δ-globin gene .
Western Blot: Human Heart Tissue, 1:200-1:2000; IHC: Human Lymphoma, 1:20-1:200; IF: Hela, 1:20-1:200
Type: Primary
Antigen: DLX4
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat