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Anti-ERO1A Rabbit Polyclonal Antibody

Supplier: Proteintech
ERO1L, also named as ERO1-alpha, is an essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. It acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. It does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Glutathione may be required to regulate its activity in the endoplasmic reticulum. It may be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress. It is required for the folding of immunoglobulin proteins. Responsible for the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. This antibody has no cross reaction to ERO1L.

Western Blot: Mouse ovary Tissue, 1:200-1:1000; IHC: Human pancreas cancer Tissue, 1:20-1:200; FC: HeLa Cells, N/A

Type: Primary
Antigen: ERO1A
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
150 µL 12007-1-AP 10081-302 Each (150µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol ERO1A
Antigen Name Endoplasmic Reticulum Oxidoreductase Alpha
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ELISA Yes
ImmunoChemistry Yes
Flow Cytometry Yes
Antigen Synonyms ERO1L, ERO1-alpha, ERO1-L-alpha, Ero1alpha, ERO1LA, ERO1-L
Immunogen Recombinant Protein
Purification Antigen affinity Purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Shipping Temperature Store at -20°C
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