Primary microcdphaly refers to the clinical finding of a head circumference less than 3 standard deviations(SD) below the age- and sex-related mean, present at birth. MCPH1, the fisrt gene identified as causative for primary microcephaly, encodes a multifunctional protein that notably is linked to DNA damage checkpoint, DNA repair by homologous recombination and DNA transcription. MCPH1 is associated with premature chromosome condensation in particular. There are two mainly isoforms encoded by MCPH1 gene, isoform1(~100kd) and isoform2(~66kd)
Western Blot: HeLa Cells, 1:200-1:2000; IHC: Human Prostate Cancer Tissue, 1:20-1:200
Type: Primary
Antigen: BRIT1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse