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Anti-SRPX2 Rabbit Polyclonal Antibody

Supplier: Proteintech
SRPX2 (sushi-repeat-containing protein, X-linked 2) is a secreted protein expressed in neurons of the human adult brain, including the rolandic area . Firstly described as sushi-repeat protein up-regulated in leukemia (SPRUL) in leukemia cells with dysregulated expression at the transcriptional level, SRPX2 has been recently shown as a multifunctional protein. SRPX2 is a ligand for uPAR, the urokinase-type plasminogen activator (uPA) receptor . It is involved in seizure disorders, angiogenesis and cellular adhesion . The involvement of SRPX2 in disorders of language cortex and cognition suggests it has an important role in the perisylvian region critical for language and cognitive development .

Western Blot: Human Placenta Tissue, 1:500-1:5000; IHC: Human Placenta Tissue, 1:20-1:200

Type: Primary
Antigen: SRPX2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
150 µL 11845-1-AP 10095-188 Each (150µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol SRPX2
Antigen Name Sushi-Repeat Containing Protein, X-Linked 2
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ELISA Yes
ImmunoChemistry Yes
Antigen Synonyms migration and adhesion through FAK signaling in gastric and other cancer cells. Localized to the cytoplasm, including the rolandic area. It has been suggested that SRPX2 enhances cell motility, SRPX2 is a ligand for uPAR urokinase plasminogen activator, a receptor that is a crucial component of the extracellular plasminogen proteolysis system. SRPX2 may be responsible for rolandic seizures RSs associated with oral and speech dyspraxia and mental retardation MR. The involvement of SRPX2 in these disorders suggests an important role for SRPX2 in the perisylvian region critical for language and cognitive development, SRPX2_HUMAN., SRPX2 is a 465 amino acid secreted protein expressed in neurons of the brain
Immunogen Recombinant Protein
Purification Antigen affinity Purification
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Shipping Temperature Store at -20°C
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