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Anti-PFN1 Rabbit Polyclonal Antibody

Supplier: Proteintech

Anti-PFN1 Rabbit Polyclonal Antibody

Anti-PFN1 Rabbit Polyclonal Antibody

Anti-PFN1 Rabbit Polyclonal Antibody

Anti-PFN1 Rabbit Polyclonal Antibody

11680-1-AP-150UL

10092-804EA 459.7 USD

10092-804

Anti-PFN1 Rabbit Polyclonal Antibody

Antibodies

Profilin-1 (PFN1) plays an important role in the control of actin dynamics, and could represent an important therapeutic target in several diseases. PFN1 is identified as a huntingtin aggregation inhibitor, and may serves as a tumor-suppressor. PFN1 is crucial for the conversion of monomeric (G)-actin to filamentous (F)-actin. Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disorder resulting from motor neuron death. Cells expressing PFN1 mutants contain ubiquitinated, insoluble aggregates that in many cases contain the ALS-associated protein TDP-43. Recently, PFN1 is a potential biomarker for bladder cancer aggressiveness and may be of great clinical importance.

Western Blot: Human Brain Tissue, 1:1000-1:10000; IHC: Human Colon cancer Tissue, 1:20-1:200

Type: Primary
Antigen: PFN1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

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