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Anti-WSB1 Rabbit Polyclonal Antibody

Supplier: Proteintech
WSB1 (or SWIP1) gene encodes WD repeat and SOCS box-containing protein 1, a member of the WD-protein subfamily. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding 3 distinct isoforms have been found for this gene. WSB1 serves as a probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WSB1 has been reported , initiated by the interaction of the two components . WSB1 is also a part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) .

Western Blot:SGC-7901 Cells, 1:500-1:5000; IHC: Human Prostate Cancer Tissue, 1:20-1:200; IF: HepG2 Cells, 1:10-1:100

Type: Primary
Antigen: WSB1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human



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Size Supplier No. VWR Catalog Number Unit Price Quantity
150 µL 11666-1-AP 10097-146 Each (150µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol WSB1
Antigen Name WD Repeat and SOCS Box Containing 1
Reactivity Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ELISA Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
Antigen Synonyms WD repeat and SOCS box-containing protein 1, SWIP1, WD repeat and SOCS box containing 1, SOCS box-containing WD protein SWiP-1, WSB-1
Immunogen Recombinant Protein
Purification Antigen affinity Purification
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Shipping Temperature Store at -20°C
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