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Anti-CDC6 Rabbit Polyclonal Antibody

Supplier: Proteintech
CDC6, also named as CDC18L and HsCDC18, belongs to the CDC6/cdc18 family. It is involved in the initiation of DNA replication and functions as a regulator at the early steps of DNA replication. The active Cdc6 functioning as a dimer at replication origins (10793143,15096526). It also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Defects in CDC6 are the cause of Meier-Gorlin syndrome type 5 (MGORS5). MGORS5 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human CDC6.

Western Blot: HeLa Cells, 1:1000-1:10000; IHC: Human Colon cancer Tissue, 1:20-1:200; IF: HepG2 Cells, 1:20-1:200

Type: Primary
Antigen: CDC6
Clonality: Polyclonal
Clone: 0
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity:



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Size Supplier No. VWR Catalog Number Unit Price Quantity
150 µL 11640-1-AP 10084-496 Each (150µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol CDC6
Antigen Name Cell Division Cycle 6
Reactivity Rat, Human, Mouse
Conjugation Unconjugated
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ELISA Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
ChIP Yes
Antigen Synonyms HsCDC18, Hscell division cycle 6, CDC18L
Immunogen Recombinant Protein
Purification Antigen affinity Purification
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Shipping Temperature Store at -20°C
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