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Anti-VPRBP Rabbit Polyclonal Antibody

Supplier: Proteintech
11612-1-AP
VprBP was first identified as a protein that can interact with HIV-1 viral protein R . It is a component of the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex that could interact with HIV-1 virus Vpr protein and HIV-2 virus Vpx protein . VprBP is a 1,507-amino acid protein that contains conserved domains, including YXXY repeats, the Lis homology motif, and WD40 repeats. Through binding to Vpr, VprBP allows Vpr to modulate the catalytic activity of the CUL4-DDB1 complex, which in turn leads to the induction of G2 phase arrest in the virus-infected cells . Recently it has been reported that VprBP is able to regulate the p53-induced transcription and apoptotic pathway .

Western Blot: HeLa Cells, 1:500-1:5000; IHC: Human Prostate Cancer Tissue, 1:20-1:200; IP: HeLa Cells, 1:500-1:5000; FC: HeLa Cells, N/A

Type: Primary
Antigen: VPRBP
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
150 µL 11612-1-AP 10096-998 Each (150µl) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol VPRBP
Antigen Name Vpr (HIV-1) Binding Protein
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ELISA Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
Flow Cytometry Yes
Antigen Synonyms DCAF1
Immunogen Recombinant Protein
Purification Antigen affinity Purification
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Shipping Temperature Store at -20°C
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