TMPRSS4, also named as CAPH2 and MT-SP2, belongs to the peptidase S1 family. TMPRSS4 is a novel type II transmembrane serine protease that is highly expressed on the cell surface in pancreatic, thyroid and other cancer tissues. It promotes invasion, migration and metastasis of human tumor cells by facilitating an epithelial-mesenchymal transition(EMT). TMPRSS4 is not expressed in normal pancreas or in chronic pancreatitis tissue samples, overexpression appeared to be cancer-specific.
Western Blot:BxPC-3 Cells, 1:200-1:2000; IHC: Human pancreas cancer Tissue, 1:20-1:200
Type: Primary
Antigen: TMPRSS4
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat