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Anti-DACH1 Rabbit Polyclonal Antibody

Supplier: Proteintech
10914-1-AP
DACH1, a homologue of the Drosophila dachshund gene, is a key regulator of cell fate determination during eye, leg, and brain development in the fly. Through interacting with NCoR and Smad4, DACH1 is able to inhibit the transforming growth factor-beta (TGF-beta) signaling pathway. DACH1 can inhibit breast cancer cellular proliferation via cyclin D1, suggesting a possible role in tumor suppression. Additionally, DACH1 plays an important role in negative regulation of RANKL (Receptor activator of NF-kappaB ligand ) gene expression in marrow stromal/preosteoblast cells, and loss of DACH1 expression might be involved in endometrial cancer progression. Four isoforms of DACH1 are produced by alternative splicing. This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human DACH1.

Western Blot: MCF7 Cells, 1:500-1:5000; IHC: Human Prostate Cancer Tissue, 1:20-1:200; IP: HEK-293 Cells, 1:500-1:5000

Type: Primary
Antigen: DACH1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
150 µL 10914-1-AP 10085-648 Each (150µl) Retrieving Restricted

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SPECIFICATIONS

Antigen Symbol DACH1
Antigen Name Dachshund Family Transcription Factor 1
Reactivity Mouse, Human, Rat
Conjugation Unconjugated
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ELISA Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
ChIP Yes
Antigen Synonyms DACH1, RP11-512J14.1, DACH, FLJ10138, dachshund homolog 1 (Drosophila) , dachshund homolog 1
Immunogen Recombinant Protein
Purification Antigen affinity Purification
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Shipping Temperature Store at -20°C
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