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Anti-OPTN Rabbit Polyclonal Antibody

Supplier: Proteintech
OPTN, also named as FIP2, GLC1E, HIP7, HYPL and NRP, plays a neuroprotective role in the eye and optic nerve. It is probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. OPTN may act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). OPTN may constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death. Defects in OPTN are the cause of primary open angle glaucoma type 1E (GLC1E). Defects in OPTN are a cause of susceptibility to normal pressure glaucoma (NPG). OPTN mutated in adult-onset primary open angle glaucoma. It supports the protective role of OPTN in the trabecular meshwork.

Western Blot: HeLa Cells, 1:500-1:5000; IHC: Human pancreas cancer Tissue, 1:20-1:200; IF: MCF-7 Cells, 1:10-1:100; IP: Mouse Brain Tissue, 1:200-1:2000

Type: Primary
Antigen: OPTN
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
150 µL 10837-1-AP 10091-594 Each (150µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol OPTN
Antigen Name Optineurin
Reactivity Human, Rat, Mouse
Conjugation Unconjugated
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ELISA Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
ImmunoFluorescence Yes
Antigen Synonyms Injury inducible protein I 55, Huntingtin-interacting protein 7, TFIIIA-IntP, NRP, Optic neuropathy-inducing protein, FIP-2, Huntingtin interacting protein HYPL, E3 14.7K interacting protein, Glaucoma 1 open angle E (adult onset), Huntingtin yeast partner L, Tumor necrosis factor alpha inducible cellular protein containing leucine zipper domains., HYPL, Ag9 C5, TFIIIA IntP, NEMO related protein, 14.7K interacting protein, FIP2, Huntingtin-interacting protein L, HIP 7, OPTN, Transcription factor IIIA-interacting protein, Optineurin, Optic neuropathy inducing protein, GLC1E, NEMO-related protein, Transcription factor IIIA interacting protein, HIP7, Glaucoma 1 open angle E, Huntingtin interacting protein 7, ALS12, E3-14.7K-interacting protein, OPTN_HUMAN, HIP-7, Huntingtin interacting protein L, FIP 2
Immunogen Recombinant Protein
Purification Antigen affinity Purification
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Shipping Temperature Store at -20°C
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