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Anti-ATF4 Rabbit Polyclonal Antibody

Supplier: Proteintech
ATF4 is a transcription factor, that accumulates predominantly in osteoblasts, where it regulates terminal osteoblast differentiation and bone formation. As a basic leucine-zipper (bZip) transcription factor, ATF4 can regulate amino acid metabolism, cellular redox state, and anti-stress responses. It also regulates age-related and diet-induced obesity and glucose homeostasis in mammals, and has conserved metabolic functions in flies. Due to its location at chromosome 22q13, a region linked to schizophrenia, ATF4 is considered as a positional candidate gene for schizophrenia. Otherwise, since ATF4 is induced by tumour microenvironmental factors, and regulates processes relevant to cancer progression, it might serve as a potential therapeutic target in cancer. Endogenous ATF4 protein has a molecular mass of 50kd. . This antibody is a rabbit polyclonal antibody raised against full length human ATF4 antigen. The antibody recognizes the 38kd ATF4 protein and its phosphorylated forms (50kd).

Western Blot:A431 Cells, 1:200-1:2000; IHC: Human breast cancer Tissue, 1:20-1:200; IP: HEK-293 Cells, 1:200-1:1000; FC: MCF-7 Cells, N/A

Type: Primary
Antigen: ATF4
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat



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Size Supplier No. VWR Catalog Number Unit Price Quantity
150 µL 10835-1-AP 10083-232 Each (150µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol ATF4
Antigen Name Activating Transcription Factor 4
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ELISA Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
Flow Cytometry Yes
Antigen Synonyms Activating transcription factor 4, CREB2, cAMP-responsive element-binding protein 2, TaxREB67, Cyclic AMP-responsive element-binding protein 2, cAMP-dependent transcription factor ATF-4, DNA-binding protein TAXREB67, CREB-2, Cyclic AMP-dependent transcription factor ATF-4, TXREB, Tax-responsive enhancer element-binding protein 67, ATF4
Immunogen Recombinant Protein
Purification Antigen affinity Purification
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Shipping Temperature Store at -20°C
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