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Anti-TDP43 Rabbit Polyclonal Antibody

Supplier: Proteintech
The TARDBP gene encodes the TDP-43 protein, initially found to repress HIV-1 transcription by binding TAR DNA. TDP-43 has since been shown to bind RNA as well as DNA, and have multiple functions in transcriptional repression, translational regulation and pre-mRNA splicing. For instance, it is reported to regulate alternate splicing of the CTFR gene.
In 2006 Neumann et al. found that hyperphosphorylated, ubiquitinated and/or cleaved forms of TDP-43, collectively known as pathological TDP-43, play a major role in the disease mechanisms of ubiquitin-positive, tau- and alpha-synuclein-negative frontotemporal dementia (FTLD-U) and in amyotrophic lateral sclerosis (ALS).
Proteintech’s 10782-2-AP antibody is a rabbit polyclonal antibody recognizing N-terminal TDP-43. Generated using the first 260 amino acids of TDP-43, it recognizes the intact 45 kDa protein as well as all posttranslationally modified and truncated forms in multiple applications.

Western Blot:K-562 Cells, 1:1000-1:10000; IHC: Human Brain (FTLD-U) Tissue, 1:20-1:200; IF: HepG2 Cells, 1:20-1:200; IP: HeLa Cells, 1:200-1:2000; FC: HeLa Cells, N/A

Type: Primary
Antigen: TDP43
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat, Zebrafish



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Size Supplier No. VWR Catalog Number Unit Price Quantity
150 µL 10782-2-AP 10082-240 Each (150µl) Retrieving Restricted
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SPECIFICATIONS

Antigen Symbol TDP43
Antigen Name TAR DNA binding Protein
Reactivity Zebrafish, Human, Rat, Mouse
Conjugation Unconjugated
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ELISA Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
ImmunoFluorescence Yes
Flow Cytometry Yes
Antigen Synonyms ALS10, TARDBP, SIG-39854-100, TDP 43
Immunogen Recombinant Protein
Purification Antigen affinity Purification
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Shipping Temperature Store at -20°C
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