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Anti-REDD1 Rabbit Polyclonal Antibody

Supplier: Proteintech
10638-1-AP
REDD1, also named as RTP801 and DDIT4, belongs to the DDIT4 family. REDD1 promotes neuronal cell death. It is a novel transcriptional target of p53 implicated ROS in the p53-dependent DNA damage response. REDD1 controlled cell growth under energy stress, as an essential regulator of TOR activity through the TSC1/2 complex. REDD-1 expression has also been linked to apoptosis, Aβ toxicity and the pathogenesis of ischemic diseases. As an HIF-1-responsive gene, REDD-1 exhibits strong hypoxia-dependent upregulation in ischemic cells of neuronal origin. In response to stress due to DNA damage and glucocorticoid treatment, REDD-1 is upregulated at the transcriptional level. REDD-1 negatively regulates the mammalian target of Rapamycin, a serine/threonine kinase often referred to as mTOR. It is crucial in the coupling of extra- and intracellular cues to mTOR regulation. The absence of REDD-1 is associated with the development of retinopathy, a major cause of blindness. REDD1 is a new host defense factor, and chemical activation of REDD1 expression represents a potent antiviral intervention strategy. REDD1 has a predicted molecular weight of 25kd. Because of multiple lysines in the proteins, REDD1 offen migrates around 35KD on Western blot. This antibody is a rabbit polyclonal antibody raised against full length human REDD1 antigen. This antibody is specific ti the REDD1 from siRNA experiment

Western Blot:K-562 Cells, 1:500-1:5000; IHC: Human lung cancer Tissue, 1:20-1:200; IP: MCF-7 Cells, 1:200-1:2000

Type: Primary
Antigen: REDD1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
150 µL 10638-1-AP 10093-496 Each (150µl) Retrieving Restricted

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SPECIFICATIONS

Antigen Symbol REDD1
Reactivity Mouse, Human, Rat
Conjugation Unconjugated
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Isotype IgG
Western Blot Yes
ELISA Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
Immunogen Recombinant Protein
Purification Antigen affinity Purification
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Shipping Temperature Store at -20°C
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