Anti-TNFRSF18 Rat Monoclonal Antibody [clone: DTA-1]

Supplier: Tonbo Biosciences
40-5874-U500 40-5874-U100
10141-186EA 667.91 USD
10141-186 10141-184
Anti-TNFRSF18 Rat Monoclonal Antibody [clone: DTA-1]
Antibodies
The DTA-1 antibody reacts with mouse CD357, also known as GITR or AITR (in humans), a 66-70 kDa member of the Tumor Necrosis Factor superfamily (TNFRSF18). GITR is primarily found on T cells, and its function may vary depending on the T cell type where it is expressed. GITR is upregulated on activated T cells where it provides co-stimulation, yet GITR may promote the inhibition of CD4+ CD25+ Treg cells, where it is expressed at high levels. GITR ligand (GITRL) is found on B cells, macrophages, dendritic and endothelial cells, and is implicated in regulating both innate and adaptive immune responses.

The DTA-1 antibody may be used for analysis of GITR expression on T cells, and is also commonly used in vitro as an agonistic antibody to induce GITR signaling in various assays.

Type: Primary
Antigen: TNFRSF18
Clonality: Monoclonal
Clone: DTA-1
Conjugation:
Epitope:
Host: Rat
Isotype: IgG2b
Reactivity: Mouse
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