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Anti-TNFRSF18 Rat Monoclonal Antibody [clone: DTA-1]

Supplier: Tonbo Biosciences

The DTA-1 antibody reacts with mouse CD357, also known as GITR or AITR (in humans), a 66-70 kDa member of the Tumor Necrosis Factor superfamily (TNFRSF18). GITR is primarily found on T cells, and its function may vary depending on the T cell type where it is expressed. GITR is upregulated on activated T cells where it provides co-stimulation, yet GITR may promote the inhibition of CD4+ CD25+ Treg cells, where it is expressed at high levels. GITR ligand (GITRL) is found on B cells, macrophages, dendritic and endothelial cells, and is implicated in regulating both innate and adaptive immune responses.

The DTA-1 antibody may be used for analysis of GITR expression on T cells, and is also commonly used in vitro as an agonistic antibody to induce GITR signaling in various assays.

Type: Primary
Antigen: TNFRSF18
Clonality: Monoclonal
Clone: DTA-1
Conjugation:
Epitope:
Host: Rat
Isotype: IgG2b
Reactivity: Mouse




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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µg 40-5874-U100 10141-184 Each (100µG) Retrieving Restricted
500 µg 40-5874-U500 10141-186 Each (500µG) Retrieving Restricted
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SPECIFICATIONS

Antibody Type Primary
Antigen Name Tumor Necrosis Factor Receptor Superfamily Member 18
Antigen Symbol TNFRSF18
Antigen Synonyms TNFRSF18, Glucocorticoid-induced TNFR-related Protein, Tumor Necrosis Factor Receptor Superfamily Member 18, Activation-inducible TNFR Family Receptor, CD357, AITR CD357, TNFRSF18, Glucocorticoid-induced TNFR-related Protein, Activation-inducible TNFR Family Receptor, Tumor Necrosis Factor Receptor Superfamily Member 18, AITR
Clonality Monoclonal
Clone DTA-1
Flow Cytometry Yes
Gene ID 21936
Host Rat
Isotype IgG2b
Neutralization Yes
Reactivity Mouse
Storage Temperature Store undiluted at 2-8°C, protect from light, do not freeze.
Tested Applications Functional Assay
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