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Neurturin Recombinant Protein, ProSci Inc

Supplier: Prosci
40-500
Neurturin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Persephin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Neurturin signals through a multicomponent receptor system, composed of RET and one of four GFR alpha (alpha1-alpha4) receptors. Neurturin promotes the development and survival of sympathetic and sensory neurons by signaling through a receptor system composed of RET and GFRalpha2. The functional form of human Neurturin is a disulfide-linked homodimer, of two 11.8 kDa polypeptide monomers (206 total amino acid residues). Each monomer contains seven conserved cysteine residues, one of which (Cys 69) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.

Store in working aliquots at -20°C. Avoid freeze/thaw cycles.




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.005 mg 40-500 10072-596 Each (5µG) Retrieving

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Protein/Peptide Name Neurturin
Protein Synonyms Neurturin, NTN
Protein/Peptide Type Recombinant
Species Human
Source E. coli
Purity >98%
Formulation Lyophilized
Biological Activity Human Neurturin at a concentration of 100 ng/mL will support the survival of 65% of newborn rat sympathetic neurons.
Protein Type Recombinant
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