Anti-PRMT5 Rabbit Polyclonal Antibody

Supplier: Prosci

10074-562EA 680.04 USD
Anti-PRMT5 Rabbit Polyclonal Antibody
Human Skb1Hs methyltransferase (also called JBP1), a homologue of yeast protein Skb1 and Hsl7p is composed of 637 amino acid residues and contains motifs conserved among protein methyltransferases. It methylates histones and MBP in vitro. Yeast Hsl7p is involved in regulation of cell cycle progression through G2 by negatively regulating Swe1p, a protein tyrosine kinase that phosphorylates and inhibits Cdc28p. An Hsl7p homologue, Skb1, was identified in fission yeast by virtue of its yeast twohybrid interaction with Shk1p, a p21 (cdc42p/Rac) activated kinase (PAK). Both proteins belong to the protein methyltransferase superfamily. Interestingly, human Skb1Hs methyltransferase was shown to interact with Jak kinases. This suggests the possibility that the Skb1Hs methyltransferase could link Jak to a PAK signaling pathway in mammalian cells. Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry (paraffin sections), and Immunocytochemistry (ABC). Other applications have not been tested. Detects endogenous levels of total human Skb1Hs methyltransferase protein. Does not crossreact with other related mammalian methyltransferases.

PRMT5 antibody can be used in Western Blot starting at 1 μg/mL, and immunohistochemistry starting at 20 μg/mL.

Protein A Column

10 mM HEPES, pH 7.5, 150 mM NaCl, 0.1 mg/mL BSA, 50% glycerol. No preservative added.

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type: Primary
Antigen: PRMT5
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Isotype: IgG
Reactivity: Human, Monkey, Mouse, Rat
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