Anti-PTPN13 Rabbit Polyclonal AntibodySupplier: Prosci
10079-208EA 582.9 USD10079-208
Anti-PTPN13 Rabbit Polyclonal Antibody
Fas-associated phosphatase-1 (FAP-1), a NT7 non-receptor protein tyrosine phosphatase, is comprised of a N-terminal FERM domain, five PDZ domains, and a C-terminal tyrosine phosphatase domain. The protein has been shown to bind the cytosolic tail of Fas (Apo1, CD95) and regulate Fas-induced apoptosis. Human tumor cell lines become resistant to Fas-mediated apoptosis when transfected with FAP-1, indicating that FAP-1 functions as a negative regulator in Fas-mediated death signaling. FAS resistance has been documented in a variety of cancers, including cancer of the lung, ovary, pancreas, and liver. At least three protein isoforms of FAP-1 have been reported. Alterations in FAP-1 expression have been shown to result in defects in cytokinesis.
PTPN13 antibody can be used in ELISA starting at 1:10000 - 1:50000, Western Blot starting at 1:5000 - 1:10000, and immunohistochemistry starting at 1:500.
Protein G Column
PBS, 0.1% sodium azide.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.