Anti-CASP12 Rabbit Polyclonal Antibody

Supplier: Prosci

49-614
10079-094EA 624.31 USD
10079-094
Anti-CASP12 Rabbit Polyclonal Antibody
Antibodies
Caspases mediate essential key proteolytic events in inflammatory cascades and the apoptotic cell death pathway. Caspase 12 is involved in the apoptosis triggered by a stress on the endoplasmic reticulum. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer’s disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase 12 activation results in cell death in the absence of the cytochrome c-dependent pathway. Recently caspase-12 has been suggested to affect signaling pathways linking some G-protein coupled receptors to alphaIIbbeta3 activation. Caspase-12 is ubiquitously expressed in mouse tissues.

Caspase-12 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 10 μg/mL.

PBS, 0.02% sodium azide.

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type: Primary
Antigen: CASP12
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat
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