Anti-APAF1 Rabbit Polyclonal Antibody

Supplier: Prosci

49-610
10079-086EA 647.66 USD
10079-086
Anti-APAF1 Rabbit Polyclonal Antibody
Antibodies
Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations. Apaf1-deficient embryos display an interesting phenotype in the inner ear and in limb development, which involves different caspase-dependent and -independent pathways. Moreover, APAF1 is mutated in human melanomas, and its depletion contributes to malignant transformation in a mouse model of cancer.

APAF1 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 2.5 ?g/mL.

Purified

PBS, 0.02% sodium azide.

Aliquot and store at 4ºC. Avoid freezing.

Type: Primary
Antigen: APAF1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat
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