Anti-NES Rabbit Polyclonal Antibody

Supplier: Prosci

10076-420EA 615.27 USD
Anti-NES Rabbit Polyclonal Antibody
Nestin, is a large intermediate filament protein (class Type VI) that was first identified with a monoclonal antibody by Hockfield and McKay (1985). Nestin is expressed predominantly in stem cells of the central nervous system in the neural tube. Nestin is expressed during development and in myotendinous and neuromuscular junctions. Nestin expression is restricted, typically disappearing by E18. Nestin is thought to be a reasonable neuronal marker; however, recent studies have found nestin expression in other cell types such as endothelial cells. Nestin expression is seen in almost all GBMs (Glioblastoma mulitformes) and many melanomas (both primary and metastatic) but not in any metastatic carcinomas. Upon terminal neural differentiation, nestin is downregulated and replaced by neurofilaments.

Nestin antibody can be used in ELISA starting at 1:1000 - 1:6000, Western Blot, and immunohistochemistry starting at 5 ?g/mL.

0.02 M potassium phosphate, 0.15 M NaCl, pH 7.2, 0.01% sodium azide.

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type: Primary
Antigen: NES
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Reactivity: Human, Mouse
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