Anti-S100 A1 Rabbit Polyclonal Antibody

Supplier: Prosci

10079-048EA 582.9 USD
Anti-S100 A1 Rabbit Polyclonal Antibody
S-100 protein derived from brain tissue is an acidic calcium-binding protein with molecular weight of about 21 kDa. In human brain tissue S-100 protein is mainly presented as two isoforms - bb homodimer (S-100b) and ab heterodimer (S-100a). Because of its predominant location in astroglial cells S-100 protein can be used as a sensitive and reliable marker for central nervous system injury. Structural damage of glial cells causes leakage of S-100 protein into the extracellular matrix and into cerebrospinal fluid, further releasing into the bloodstream. Measurements of S-100 protein in patient serum samples are useful in monitoring of traumatic brain injury, ischemic brain damage after circulatory arrests, and in diagnosis and prognosis of clinical outcome in acute stroke. Although predominant among the water-soluble brain proteins, S-100 is also found in a variety of other tissues. S-100 is an intracellular protein that weakly binds calcium. It binds zinc very tightly, however, and this appears to increase the affinity of the protein for calcium. Distinct binding sites, with different affinities, exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.

S100 Protein antibody can be used in ELISA starting at 1:2000 - 1:4000, Western Blot starting at 1:2000 - 1:4000, immunohistochemistry starting at 5 µg/mL, and immunoprecipitation

Protein A Column

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type: Primary
Antigen: S100A1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Reactivity: Bovine, Human
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