Anti-NRF1 Rabbit Polyclonal Antibody

Supplier: ProSci
49-493
10079-030EA 674.53 USD
10079-030
Anti-NRF1 Rabbit Polyclonal Antibody
Antibodies
NRF1 (also known as nuclear respiratory factor 1, alpha palindromic binding protein and alpha-pal) is the mammalian homolog to the erect wing (ewg) Drosophila protein that is required for proper development of the central nervous system and indirect flight muscles. In mammals NRF1 functions as a transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. This protein links the transcriptional modulation of key metabolic genes to cellular growth and development and has been implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. NRF1 forms a homodimer and binds DNA as a dimer. NRF1 shows a nuclear localization and is widely expressed in embryonic, fetal, and adult tissues. Phosphorylation of NRF1 enhances DNA binding. Multiple splice variants have been identified for this protein.

  • NRF1 antibody can be used in Western Blot starting at 0.5 - 4 μg/mL, immunohistochemistry starting at 2.5 μg/mL, immunohistochemistry in frozen tissues starting at 10 - 20 μg/mL, and immunoprecipitation starting at 10 - 20 μg/mL

Protein A Column

0.02 M potassium phosphate, 0.15 M NaCl, pH 7.2, 0.01% sodium azide.

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type: Primary
Antigen: NRF1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human, Mouse
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