Anti-PRKDC Rabbit Polyclonal Antibody

Supplier: Prosci

10078-998EA 615.09 USD
Anti-PRKDC Rabbit Polyclonal Antibody
DNA dependent Protein Kinase (also called DNAPK, DNPK1, HYRC1, Protein Kinase DNA Activated Catalytic Polypeptide, XRCC7 and p460) consists of the 460 kDa DNA PKcs and a heterodimeric regulatory complex comprised of p70 Ku and p80 Ku (Ku autoantigen). DNA PKcs is a nuclear protein serine/threonine kinase present in a wide variety of eukaryotic species. DNA PKcs phosphorylates transcription factors, Sp1, Oct-1, p53 and SV40 large T antigen. DNA PKcs is involved in repairing double stranded DNA breaks. At the onset of apoptosis, DNA PKcs is rapidly inactivated by cleavage of the catalytic subunit into smaller polypeptides. Proteolysis of DNA PKcs is inhibited by the cysteine protease inhibitors iodoacetamide and N-ethylmaleimide. Alternative splicing can occur for this protein to produce at least two isoforms.

PRKDC antibody can be used in ELISA starting at 1:4000 - 1:16000, Western Blot starting at 1:500 - 1:3000, and immunohistochemistry starting at 10 - 20 ?g/mL.

0.02 M potassium phosphate, 0.15 M NaCl, pH 7.2, 0.01% sodium azide.

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type: Primary
Antigen: PRKDC
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Reactivity: Chimpanzee, Human
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